The concomitant use of opioids with other medications that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome.

It is actually soluble in h2o and freely soluble in Alcoholic beverages. The molecular body weight is 320.88. Its molecular formulation is C17H20N2S•HCl, and it's the subsequent chemical composition.

By way of example, quite a few described instances of death happened in the article-operative time period pursuing tonsillectomy and/or adenoidectomy, and many of the kids experienced evidence of staying extremely-rapid metabolizers of codeine. Furthermore, kids with obstructive slumber apnea who're taken care of with codeine for post-tonsillectomy and/or adenoidectomy soreness might be specifically sensitive to its respiratory depressant impact. As a result of possibility of life-threatening respiratory melancholy and Demise:

Get professional medical aid immediately for those who observe any of the subsequent: slow/shallow respiratory, serious drowsiness/issues waking up, confusion.

However it helps A lot of people, this medication includes a threat for abuse and may in some cases bring about habit. This danger may be higher if you have a compound use problem (which include overuse of or dependancy to medicines/alcohol).

Opioids can lessen the efficacy of diuretics by inducing the discharge of antidiuretic hormone. Monitor individuals for signs of diminished diuresis and/or results on blood pressure level and raise the dosage with the diuretic as required.

Opioid medicine can slow or prevent your respiration, and death may occur. Someone caring for you must seek out emergency professional medical interest For those who have slow breathing with lengthy pauses, blue colored lips, or Should you be tough to get up.

Prior to employing this medication, women of childbearing age must converse with their medical professional(s) in regards to the pitfalls and Gains. Explain to your physician When you are pregnant or Believe you may well be pregnant. Through pregnancy, this medication is not suggested. It could somewhat enhance the chance of birth defects if used over the to start with two months of pregnancy. Also, employing it for a long time or in high doses near the expected delivery date may perhaps damage the unborn little one.

Promethazine need to be utilized cautiously in folks with heart problems or with impairment of liver functionality.

Due to dangers of habit, abuse, and misuse with opioids, even at proposed doses, reserve Promethazine with Codeine Oral Answer for use in Grownup patients more info for whom the advantages of cough suppression are anticipated to outweigh the dangers, and in whom an enough assessment of the etiology on the cough has long been produced.

Utilize other supportive steps (which include oxygen and vasopressors) inside the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias would require Innovative life-aid tactics. Gastric emptying could possibly be beneficial in removing unabsorbed drug.

Impaired secretion from sweat glands following harmful doses of drugs with anticholinergic Unwanted effects may possibly predispose to hyperthermia.

You should not use Promethazine VC with Codeine When you are allergic to codeine, phenylephrine, or promethazine, or if you have:

If you're getting any of these medicine: Buprenorphine, butorphanol, nalbuphine, or pentazocine. When you have been advised by your health care provider that you're a quick metabolizer of some medicine. If you are breast-feeding. Usually do not breast-feed When you acquire promethazine and codeine. It's not an index of all medications or medical problems that interact with promethazine and codeine. Tell your medical professional and pharmacist about your entire drugs (prescription or OTC, all-natural products, natural vitamins) and health issues. You must Check out to make sure that it's Protected for you to get promethazine and codeine with your whole medications and health conditions. Will not get started, prevent, or change the dose of any drug without examining with your health care provider. Similar/identical drugs